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Related Experiment Videos

FcgammaRIIIA-158V and rheumatoid arthritis: a confirmation study.

A W Morgan1, V H Keyte, S J Babbage

  • 1Rheumatology and Rehabilitation Research Unit, University of Leeds, UK. a.w.morgan@leeds.ac.uk

Rheumatology (Oxford, England)
|March 22, 2003
PubMed
Summary

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The FcgammaRIIIA-158V allele is linked to rheumatoid arthritis (RA) and nodules in UK Caucasians. Homozygosity for this allele increases RA risk and nodule development, suggesting FcgammaRIIIA

Area of Science:

  • Immunogenetics
  • Rheumatology
  • Molecular Biology

Background:

  • The FcgammaRIIIA-158V/F polymorphism influences immune responses.
  • Rheumatoid arthritis (RA) is a complex autoimmune disease with genetic components.
  • Previous studies suggested a link between FcgammaRIIIA-158V and RA, but robust data were lacking.

Purpose of the Study:

  • To establish a reliable method for genotyping the FcgammaRIIIA-158V/F polymorphism.
  • To investigate the association between the FcgammaRIIIA-158V allele and rheumatoid arthritis (RA) in a UK population.
  • To explore the relationship between this polymorphism and RA disease characteristics, such as nodules.

Main Methods:

  • An allelic association study design was employed.
  • A novel single-stranded conformational polymorphism (SSCP) assay was developed and utilized for genotyping.

Related Experiment Videos

  • The study included 828 RA patients and 581 healthy controls from the United Kingdom.

    • Main Results:

    • The FcgammaRIIIA-158V allele showed a significant association with RA (P=0.02).
    • Individuals homozygous for the FcgammaRIIIA-158V allele had an increased risk of developing RA (OR 1.53) and nodules (OR 2.20).
    • A significant association was also observed between the FcgammaRIIIA-158V allele and the presence of nodules (P=0.04).

    Conclusions:

    • A novel and robust assay for FcgammaRIIIA-158F/V genotyping was successfully developed.
    • Homozygosity for the FcgammaRIIIA-158V allele is confirmed as a risk factor for rheumatoid arthritis in UK Caucasians.
    • The FcgammaRIIIA-158V allele appears to play a role in disease severity, particularly in the development of nodules.