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Translocation Down syndrome
A Jyothy1, G N Mallikarjuna Rao, K S D Kumar
1Institute of Genetics, Osmania University, Begumpet, Hyderabad-500 016.
Indian Journal of Medical Sciences
|March 26, 2003
Abstract:
Cytogenetic investigations carried out on 1021 cases of Down syndrome revealed translocation in 46 cases. The most frequent was of t(14;21) and t(21;21) types. Most of the translocation DS cases (n = 31) were born to younger mothers (< 25 years), when compared to pure trisomy 21 DS cases. Parental karyotypes, family history and parental ages has helped us greatly in offering genetic counseling, prenatal diagnosis and estimating the risk for the next conception.