Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endocrine responses to space flights.

L Macho1, R Kvetnansky, M Fickova

  • 1Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava.

Journal of Gravitational Physiology : a Journal of the International Society for Gravitational Physiology
|March 26, 2003
PubMed
Summary

Animal studies using rats in space explored how spaceflight affects bone, muscle, immunity, and endocrine functions. These experiments provide insights into human adaptation to microgravity, though in-flight data is limited.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The role of persistent viral infections with Herpes viridae and Papilloma viridae associated with chronic inflammatory pathology of the oropharynx].

Vestnik otorinolaringologii·2017
Same author

[The new approaches to the treatment of inflammatory pharyngeal pathology].

Vestnik otorinolaringologii·2015
Same author

[Urine proteome study for the evaluation of cardiovascular system state after spaceflight in human].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova·2014
Same author

[Interstitial pulmonary fibrosis: the role of angiogenic factors, the inhibitory pathways of progression].

Terapevticheskii arkhiv·2014
Same author

[Shifts in metabolism and its regulation under the effect of spaceflight factors].

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2013
Same author

[Endothelin-1 and brain natriuretic peptide in the development of pulmonary hypertension in interstitial lung diseases].

Terapevticheskii arkhiv·2010

Area of Science:

  • Space biology and medicine
  • Animal physiology
  • Endocrinology

Background:

  • Spaceflight poses unique physiological challenges to living organisms.
  • Understanding these challenges is crucial for long-duration human space missions.
  • Animal models offer valuable insights into complex biological responses to space environments.

Purpose of the Study:

  • To investigate the effects of spaceflight on bone and skeletal muscle.
  • To analyze alterations in immune system function and radiation effects.
  • To elucidate changes in endocrine functions and hormonal roles in metabolic processes.

Main Methods:

  • Experiments utilized rats exposed to spaceflight via BION-COSMOS satellites and Shuttle Transportation Systems (STS).
  • Analysis included plasma, organ, and tissue samples for morphological, biochemical, enzyme activity, and gene expression studies.

Related Experiment Videos

  • Hormone production and tissue response to hormones were investigated, alongside comparisons to other stress stimuli.

    • Main Results:

    • Spaceflight induced changes in bone, skeletal muscle, and immune function.
    • Endocrine functions, particularly the pituitary-adrenocortical, thyroid, and gonadal axes, were significantly altered.
    • Animal studies confirmed the utility of these models for verifying hypotheses on human adaptation to altered gravity.

    Conclusions:

    • Animal experiments provide comprehensive data for understanding spaceflight's impact on physiology.
    • Further research is needed to capture in-flight physiological changes.
    • Focusing on specific endocrine axes, like the pituitary-adrenocortical system, is key to understanding spaceflight adaptation.