The in vitro synthesis of 7-hydroxy dehydroepiandrosterone by human mammary tissues

Normal and tumorous human mammary tissues were incubated in vitro with [7alpha-3H] dehydroepiandrosterone and [7alpha-3H] dehydroepiandrosterone sulphate. Tritium-labelled 7alpha-hydroxy dehydroepiandrosterone was identified as a principal metabolite from four of the five studies with normal tissue and all seven studies with tumorous tissue.