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Transferrin function in zinc absorption and transport.

G W Evans

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
    |April 1, 1976
    PubMed
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    Transferrin plays a key role in zinc absorption and transport. This study shows that transferrin binds most absorbed zinc in rat portal blood, facilitating its movement.

    Area of Science:

    • Biochemistry
    • Physiology
    • Trace Element Metabolism

    Background:

    • Zinc is an essential trace element vital for numerous biological processes.
    • Understanding the mechanisms of zinc absorption and transport is crucial for human health.
    • The role of specific plasma proteins in zinc transport requires further elucidation.

    Purpose of the Study:

    • To investigate the role of transferrin in the absorption and transport of zinc.
    • To identify the primary binding protein for absorbed zinc in portal plasma.
    • To compare the zinc-binding capacity of transferrin with albumin.

    Main Methods:

    • Rats were administered 65Zn into the duodenal lumen.
    • Portal vein blood was collected, and plasma was analyzed for 65Zn binding.

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  • In vitro experiments involved incubating 65Zn-labeled basolateral membranes with apotransferrin and albumin.

    • Main Results:

    • The majority of absorbed 65Zn in portal plasma was bound to transferrin.
    • Apotransferrin effectively removed 60% of 65Zn from labeled membranes.
    • Zinc-free albumin and histidine showed significantly less capacity to remove 65Zn from membranes.

    Conclusions:

    • Transferrin is the primary protein responsible for binding and transporting absorbed zinc.
    • These findings highlight transferrin's critical function in systemic zinc distribution.
    • The study provides direct evidence for transferrin's involvement in zinc homeostasis.