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Related Experiment Videos

Pleural fluid lysozyme in human disease.

C P Burns, K K Wu, D A Barrett

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
    |May 1, 1976
    PubMed
    Summary
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    Pleural fluid lysozyme levels are similar across various diseases and show poor correlation with disease state. This suggests lysozyme in pleural fluid originates mainly from the blood, not local cells.

    Area of Science:

    • Biochemistry
    • Pulmonology
    • Clinical Pathology

    Background:

    • Lysozyme is an enzyme found in various bodily fluids.
    • Its presence and significance in pleural fluid require further investigation.

    Purpose of the Study:

    • To determine the content, significance, and source of lysozyme in human pleural fluid.
    • To assess the diagnostic value of pleural fluid lysozyme activity.

    Main Methods:

    • Prospective study design.
    • Measurement of lysozyme activity in pleural fluid and paired serum samples.
    • Correlation analysis with disease state and cell counts.

    Main Results:

    • Pleural fluid lysozyme activity showed similarity in malignant and non-malignant transudates and exudates.

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  • Activity correlated well with serum lysozyme levels.
  • Poor correlation was observed with disease state, granulocyte counts, and total white blood cell counts.

    • Conclusions:

    • Pleural fluid lysozyme activity has limited diagnostic value.
    • The primary source of pleural fluid lysozyme is likely the blood.
    • Lysozyme is not primarily produced by inflammatory or neoplastic cells within the pleural fluid.