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Related Experiment Videos

Analgesia and hyperractivity following morphine microinjection into mouse brain.

H E Criswell

    Pharmacology, Biochemistry, and Behavior
    |January 1, 1976
    PubMed
    Summary

    Morphine microinjection into the periaqueductal gray matter of mice caused dose-dependent analgesia and hyperreactivity. Strain differences in morphine-induced hyperreactivity were observed in mice.

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    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • Microinjection of morphine into the periaqueductal gray matter (PAG) in rats has been linked to analgesia and paradoxical hyperreactivity.
    • These PAG-mediated effects of morphine have not been extensively studied in other species.

    Purpose of the Study:

    • To investigate the effects of morphine microinjection into the periaqueductal gray matter in mice.
    • To determine if analgesia and hyperreactivity are dose-dependent and if strain differences exist.

    Main Methods:

    • Morphine was microinjected into the periaqueductal gray matter of several strains of mice.
    • Dose-dependent effects on analgesia and reactivity to stimuli were assessed.
    • Strain differences in response to morphine were compared.

    Main Results:

    • Both analgesia and hyperreactivity were observed as dose-dependent effects of morphine microinjection into the mouse PAG.
    • Low doses of morphine produced analgesia, while higher doses resulted in both analgesia and hyperreactivity.
    • Significant strain differences were found, with B6D2F1 mice exhibiting greater hyperreactivity to morphine than BALB/c mice.

    Conclusions:

    • Morphine microinjection into the periaqueductal gray matter induces dose-dependent analgesia and hyperreactivity in mice.
    • The observed effects are influenced by genetic factors, as evidenced by strain-specific differences in hyperreactivity.
    • These findings highlight the complex role of the PAG in modulating pain and behavioral responses to opioids.

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