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Pulmonary function in primary pulmonary hypertension.

Xing-Guo Sun1, James E Hansen, Ronald J Oudiz

  • 1Division of Respiratory and Critical Care Physiology and Medicine, Department of Medicine, Research and Education Institute, Harbor-UCLA Medical Center, Torrance, CA 90509, USA.

Journal of the American College of Cardiology
|March 26, 2003
PubMed
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Abnormalities in resting lung function, including diffusing capacity for carbon monoxide (DLCO), are common in primary pulmonary hypertension (PPH). These lung function changes significantly correlate with disease severity, aiding in the evaluation of unexplained dyspnea.

Area of Science:

  • Pulmonary Medicine
  • Cardiopulmonary Physiology

Background:

  • Primary pulmonary hypertension (PPH) diagnosis is often delayed due to subtle symptoms and the need for invasive testing.
  • Resting lung function abnormalities are known in PPH but their correlation with disease severity requires further investigation.

Purpose of the Study:

  • To determine the correlation between resting lung function abnormalities and disease severity in patients with primary pulmonary hypertension (PPH).

Main Methods:

  • Assessed resting lung mechanics and diffusing capacity for carbon monoxide (DLCO) in 79 PPH patients.
  • Correlated lung function data with cardiac catheterization, NYHA class, and exercise testing results.

Main Results:

  • Reduced DLCO and lung volumes were observed in a majority of PPH patients.

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  • Decreases in DLCO and lung volumes significantly correlated with reduced exercise capacity (peak oxygen uptake, anaerobic threshold) and higher NYHA class.

    • Conclusions:

    • Common resting lung function abnormalities, including DLCO, are significantly associated with PPH disease severity.
    • These lung function measurements can aid in assessing patients presenting with unexplained dyspnea and fatigue.