Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Notch signalling in hematopoiesis.

K Ohishi1, N Katayama, H Shiku

  • 1The Second Department of Internal Medicine, Mie University School of Medicine, 2-174 Edobashi Tsu, Mie 514-0061, Japan.

Seminars in Cell & Developmental Biology
|March 26, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antileukemia multifunctionality of CD4(+) T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer.

Leukemia·2015
Same author

Feasibility of gene-immunotherapy using WT1-specific T-cell receptor gene transfer for infant acute lymphoblastic leukemia with MLL gene rearrangement.

Blood cancer journal·2012
Same author

siRNA-mediated silencing of PD-1 ligands enhances tumor-specific human T-cell effector functions.

Gene therapy·2011
Same author

Detection of microspotted carcinoembryonic antigen on a glass substrate by scanning electrochemical microscopy.

Analytical chemistry·2011
Same author

Higher frequency of ras oncogene activation in gastric stump carcinomas due to special conditions in the gastric remnant.

Oncology reports·2011
Same author

Kinase group protooncogenes in non-hodgkins-lymphomas and nonmalignant lymphoid-tissues - analysis of their expression by insitu hybridization assays.

International journal of oncology·2011

The Notch pathway regulates cell fate decisions in development. This conserved signaling system controls whether stem cells renew themselves or differentiate into various cell types, crucial for hematopoietic development.

Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Hematopoiesis

Background:

  • The Notch pathway is an evolutionarily conserved signaling system.
  • It plays a critical role in cell fate determination for multipotent precursor cells.
  • Notch signaling influences cell survival, proliferation, and differentiation choices.

Purpose of the Study:

  • To elucidate the fundamental role of the Notch pathway in regulating hematopoietic development.
  • To understand how Notch signaling affects the fate decisions of hematopoietic stem cells and their precursors.

Main Methods:

  • Analysis of Notch receptor and ligand expression in hematopoietic and stromal cells.
  • Investigating the impact of Notch signaling on precursor cell survival, proliferation, and differentiation.

Related Experiment Videos

  • Examining Notch pathway's role in specific hematopoietic developmental stages, including stem cell self-renewal and lineage commitment.

    • Main Results:

    • Notch signaling influences whether hematopoietic stem cells self-renew or differentiate.
    • It directs the differentiation of common lymphoid precursors into T or B cells.
    • Notch pathway affects monocyte differentiation into macrophages or dendritic cells.

    Conclusions:

    • The Notch pathway is fundamental in regulating hematopoietic development.
    • It acts by inhibiting certain differentiation pathways while promoting others, thereby controlling cell fate.
    • Understanding Notch signaling is key to comprehending normal and potentially aberrant hematopoiesis.