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Updated: Sep 26, 2026

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
Minimally invasive surgical management of primary venous ulcers vs. compression treatment: a randomized clinical
P Zamboni1, C Cisno, F Marchetti
1Department of Surgical, Anaesthesiological, and Radiological Sciences, Day-Surgery Unit, University of Ferrara, Italy.
Objectives:
to compare minimally invasive surgical haemodynamic correction of reflux (CHIVA) with compression in the treatment of venous ulceration.
Design:
prospective randomised study.
Materials And Methods:
from a cohort of 80 patients with 87 venous leg ulcers, 47 were randomised to either surgery or compression.
Results:
at a mean follow-up of 3 years, healing was 100% (31 days) in the surgical and 96% (63 days), in the compression group (p<0.02). The recurrence rate was 9% in the surgical and 38% in the compression group (p<0.05). In the surgical group, all plethysmographic parameters except ejection fraction, had improved significantly at 6 months in the surgical group, and at 3 years residual volume fraction remained in the normal range. Finally, quality of life significantly improved in the operated group.
Conclusions:
this study supports the effectiveness of surgical therapy for leg ulceration secondary to superficial venous reflux.
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