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Updated: Aug 19, 2026
In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding
Published on: May 1, 2020
Immunohistochemical analysis of Fas protein expression in hypertrophic scar and keloid
Feng Lu1, Jian-hua Gao, Xiao-jian Li
1Department of Plastic Surgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Objective:
To find an efficient diagnostic method of hypertrophic scar and keloid.
Methods:
Immunohistochemistry was employed to detect the expression and distribution of Fas protein in keloids, hypertrophic scars and their surrounding normal skins. Image analysis was performed to quantitatively compare the differences of the protein expression in these tissues.
Results:
The expression level of Fas antigen was much higher in the keloids and their surrounding normal skins than in hypertrophic scars, and no significant difference in the expression level between the former 2 tissues was found. In hypertrophic scars, however, much lower Fas protein expression was detected in comparison with that in their surrounding normal skins(P < 0.01).
Conclusion:
Immunohistochemical detection of Fas protein is a simple method that is well applicable in the differential diagnosis of pathological scars.
