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Related Experiment Videos

Hyperinsulinism and overgrowth without obesity.

S Srinivasan1, M J Waters, J E Rowland

  • 1Sydney Children's Hospital, Sydney, Australia.

Archives of Disease in Childhood
|March 26, 2003
PubMed
Summary
This summary is machine-generated.

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A child

Area of Science:

  • Pediatric endocrinology
  • Growth disorders
  • Metabolic diseases

Background:

  • Postnatal overgrowth and hyperinsulinaemia can present in children.
  • Elevated insulin-like growth factor 1 (IGF-1) is often associated with growth abnormalities.
  • Pituitary abnormalities and growth hormone excess are common causes of overgrowth.

Observation:

  • A 5-year-old girl exhibited postnatal overgrowth (height velocity >97th centile) and hyperinsulinaemia.
  • She had increased insulin-like growth factor 1 for age, with no evidence of growth hormone excess or pituitary issues.
  • Over two years, she developed acanthosis nigricans and diabetes mellitus.

Findings:

  • The patient's overgrowth may stem from hyperinsulinism.
  • Her serum contains an unidentified factor stimulating lymphocyte precursor proliferation, potentially causing overgrowth.

Related Experiment Videos

  • This unidentified factor is neither insulin nor IGF-1.

    • Implications:

    • This case highlights a potential novel mechanism for childhood overgrowth.
    • The findings suggest a possible link between lymphocyte proliferation and metabolic/growth disturbances.
    • Further research is needed to identify the serum factor and its role in acanthosis nigricans and diabetes mellitus.