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Hepatosplenic cat scratch disease treated with corticosteroids
1Department of Pediatrics, University of Louisville School of Medicine, 571 S Floyd Street, Suite 321, Louisville, Kentucky 40202, USA. k0brya01@athena.louisville.edu
Archives of Disease in Childhood
|March 26, 2003
Summary
Fever in a child with hepatosplenic cat scratch disease (CSD) persisted despite multiple antibiotic treatments. Corticosteroids ultimately resolved the prolonged fever, suggesting a role beyond typical bacterial infection.
Area of Science:
- Pediatric Infectious Diseases
- Immunology
Background:
- Cat scratch disease (CSD) is a bacterial infection caused by Bartonella henselae.
- Hepatosplenic CSD can present with prolonged fever and systemic symptoms.
Observation:
- A 3-year-old girl presented with hepatosplenic CSD and persistent fever.
- The fever was unresponsive to a broad spectrum of antibiotics, including gentamicin, azithromycin, rifampin, and ciprofloxacin.
Findings:
- Corticosteroid therapy led to the resolution of the prolonged fever.
- This suggests a significant inflammatory or immune-mediated component to the fever in this case.
Implications:
- Corticosteroids may be a valuable therapeutic option for refractory fever in hepatosplenic CSD.
- Further research is warranted to elucidate the immunopathogenesis of CSD-associated fever.
