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Bladder dysfunction in Duchenne muscular dystrophy.

M MacLeod1, R Kelly, S A Robb

  • 1Department of Paediatric Neurology, Guy's Hospital, London, UK.

Archives of Disease in Childhood
|March 26, 2003
PubMed
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Urinary problems are common in Duchenne muscular dystrophy (DMD), affecting nearly half of boys studied. These bladder issues, including small capacity and hyperreflexic bladders, are treatable.

Area of Science:

  • Urology
  • Neuromuscular Disorders
  • Pediatric Medicine

Background:

  • Duchenne muscular dystrophy (DMD) is a progressive genetic disorder primarily affecting muscles.
  • Bladder function is often presumed to be unaffected in individuals with DMD.

Purpose of the Study:

  • To investigate the prevalence and characteristics of urinary dysfunction in boys with Duchenne muscular dystrophy.
  • To determine if bladder issues are a significant, treatable feature of DMD.

Main Methods:

  • Interviewed 88 boys with DMD about urinary problems.
  • Performed video urodynamics on nine boys with reported urinary issues.

Main Results:

  • 46 out of 88 boys (52%) reported urinary problems.

Related Experiment Videos

  • Video urodynamics revealed small capacity, hyperreflexic bladders in eight boys.
  • One boy with prior spinal surgery exhibited hyperreflexia and detrusor sphincter dyssynergia.

    • Conclusions:

    • Urinary dysfunction is a prevalent and often unrecognized complication of Duchenne muscular dystrophy.
    • Bladder abnormalities identified are treatable, suggesting a need for urological screening in DMD patients.