Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transition models for change-point estimation in logistic regression.

Roberto Pastor-Barriuso1, Eliseo Guallar, Josef Coresh

  • 1Department of Epidemiology and Biostatistics, National School of Public Health, Instituto de Salud Carlos III, Madrid, Spain. rpastor@isciii.es

Statistics in Medicine
|March 26, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Utility of multimodal longitudinal imaging data for dynamic prediction of cardiovascular and renal disease: the CARDIA study.

Frontiers in radiology·2024
Same author

Cost-Effectiveness of Fractional Flow Reserve-Guided Treatment for Acute Myocardial Infarction and Multivessel Disease: A Prespecified Analysis of the FRAME-AMI Randomized Clinical Trial.

JAMA network open·2024
Same author

Obstructive Sleep Apnea and Its Influence on Intracranial Aneurysm.

Journal of clinical medicine·2024
Same author

Obesity paradox in patients with non-small cell lung cancer undergoing immune checkpoint inhibitor therapy.

Journal of cachexia, sarcopenia and muscle·2023
Same author

Deleterious heteroplasmic mitochondrial mutations are associated with an increased risk of overall and cancer-specific mortality.

Nature communications·2023
Same author

Effect of Anemia on Physical Function and Physical Activity in CKD: The National Health and Nutrition Examination Survey, 1999-2016.

Kidney360·2023
Same journal

Interpretable Bayesian Modeling for Multireader Multicase Studies: Addressing Overdispersion and Limited Sample Size in Diagnostic Enhancement Evaluation.

Statistics in medicine·2026
Same journal

Adaptive Sequential Multiple Hypotheses Testing for Concomitant Vaccine Safety Surveillance.

Statistics in medicine·2026
Same journal

Novel Distance Regression for Repeated Outcomes With Missing Data: Applications to Longitudinal and Crossover Studies of Microbiome Beta-Diversity.

Statistics in medicine·2026
Same journal

Optimal Weighted Tests for Replication Studies and the 'Two-Trials Rule' With Multiple Hypotheses.

Statistics in medicine·2026
Same journal

Identifiable Copula-Double-Cox Models: A Fully Parametric Framework for Dependent Right-Censored Survival Data.

Statistics in medicine·2026
Same journal

Moving From Individualized Risk-Based Prevention to Benefit-Based Prevention: Estimating Individualized Life-Years Gained From Prevention Services as a Basis for Eligibility.

Statistics in medicine·2026
See all related articles

This study introduces new logistic regression models for analyzing dichotomous outcomes with change-points. These transition models allow for flexible estimation of dose-response relationships and change-point locations.

Area of Science:

  • Biostatistics
  • Epidemiology
  • Statistical Modeling

Background:

  • Limited change-point models exist for dichotomous outcomes.
  • Existing models often lack flexibility in modeling dose-response relationships.

Purpose of the Study:

  • To introduce novel transition methods for logistic regression models with change-points in dichotomous outcomes.
  • To provide a flexible framework for analyzing dose-response relationships with potential abrupt or gradual changes.

Main Methods:

  • Development of differentiable transition functions for logistic regression.
  • Modified iteratively reweighted least squares algorithm for parameter estimation.
  • Inference procedures including a change-point existence test.

Related Experiment Videos

Main Results:

  • The proposed transition models accommodate both intersecting and jump change-points.
  • Parametric control over transition sharpness allows for modeling gradual or abrupt changes.
  • Successful application in a simulation study and analysis of glucose-mortality association.

Conclusions:

  • The developed transition models offer a flexible and robust approach for analyzing dichotomous outcomes with change-points.
  • These methods enhance the understanding of dose-response relationships in epidemiological studies.
  • The study validates the utility of these models in real-world health data analysis.