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Progressive multifocal leukoencephalopathy.

J Kirsh, L Rosenthall, M H Finlayson

    Radiology
    |May 1, 1976
    PubMed
    Summary
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    Radiological imaging, including radionuclide scans and cerebral angiography, revealed lesions in a patient with progressive multifocal leukoencephalopathy (PML). However, these imaging techniques did not show unique features specific to PML.

    Area of Science:

    • Neurology
    • Radiology
    • Pathology

    Background:

    • Progressive multifocal leukoencephalopathy (PML) is a rare, demyelinating disease of the central nervous system.
    • Correlation of imaging findings with pathological data is crucial for understanding PML.
    • This study examines imaging characteristics in a confirmed PML case.

    Observation:

    • Radionuclide imaging identified multiple lesions, with the largest two correlating with pathological findings.
    • Repeated radionuclide scans showed a "doughnut" sign in one lesion, indicating central necrosis.
    • Cerebral angiography initially suggested tumor encasement of one lesion, later evolving into an avascular zone.

    Findings:

    • Radionuclide imaging visualized the extent of PML lesions, including those with central necrosis.

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  • Cerebral angiography demonstrated lesion evolution but lacked specific diagnostic markers for PML.
  • No imaging modality provided pathognomonic features for diagnosing PML in this case.

    • Implications:

    • Standard radionuclide imaging and cerebral angiography may not offer definitive diagnostic signs for PML.
    • Pathological correlation remains essential for confirming PML diagnoses.
    • Further research into advanced neuroimaging techniques for PML is warranted.