[Cytokine gene]

The most important aspect of cytokine gene expression in cancer is paraneoplastic syndrome. Paraneoplastic syndrome presents symptoms and signs characteristic of substances that tumors produce, some of which have been revealed to be cytokine. Detection of cytokine gene expression in paraneoplastic syndrome is important not only for diagnosis but for monitoring of anti-cytokine therapy that is expected to be rapidly developed. Proper diagnosis and treatment of paraneoplastic syndrome are also important for improving the QOL of cancer patients. In this context, recent advancement of anti-cytokine monoclonal antibody therapy is expected to aid treatment.