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Hypothalamic digoxin, cerebral dominance, and mitochondrial function/free radical metabolism
Ravi Kumar Kurup1, Parameswara Achutha Kurup
1Department of Neurology, Medical College, Trivandrum, Kerala, India.
The International Journal of Neuroscience
|March 26, 2003
Summary
Cerebral dominance impacts free radical metabolism and mitochondrial function. Right hemispheric dominance is linked to increased oxidative stress and impaired enzyme activity, while left hemispheric dominance shows the opposite biochemical profile.
Area of Science:
- Biochemistry
- Neuroscience
- Cellular Biology
Background:
- Cerebral dominance influences various physiological processes.
- Understanding biochemical differences between hemispheric dominance is crucial.
Purpose of the Study:
- To investigate biochemical distinctions in free radical metabolism and mitochondrial function.
- To compare these functions between right-hemispheric dominant and left-hemispheric dominant individuals.
Main Methods:
- Assessed plasma HMG CoA reductase activity and isoprenoid metabolites (digoxin, ubiquinone).
- Measured plasma magnesium, RBC membrane Na(+)-K+ ATPase activity, and lipid peroxidation products (malondialdehyde, hydroperoxides, conjugated dienes, NO).
- Quantified reduced glutathione, and activities of superoxide dismutase, catalase, GSH peroxidase, and GSH reductase.
Main Results:
- Right-hemispheric dominance exhibited elevated HMG CoA reductase, digoxin, lipid peroxidation, and NO.
- Conversely, decreased plasma magnesium, Na(+)-K+ ATPase activity, ubiquinone, reduced glutathione, and free radical scavenging enzymes were observed in right-hemispheric dominance.
- Left-hemispheric dominance showed inverse patterns, indicating hypodigoxinemia and stimulated Na(+)-K+ ATPase with reduced lipid peroxidation.
Conclusions:
- Right hemispheric dominance is characterized by a hyperdigoxinemic state, inhibited Na(+)-K+ ATPase, and increased lipid peroxidation.
- Left hemispheric dominance presents the reverse pattern with hypodigoxinemia, stimulated Na(+)-K+ ATPase, and decreased lipid peroxidation.
- Cerebral dominance plays a regulatory role in mitochondrial function and free radical metabolism.