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Related Experiment Videos

[Steroid induced glaucoma].

Ruth Sapir-Pichhadze1, Eytan Z Blumenthal

  • 1Department of Opthalmology, Hadassah University Hospital, Jerusalem, Israel.

Harefuah
|March 26, 2003
PubMed
Summary
This summary is machine-generated.

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Steroid medications can cause ocular hypertension and open-angle glaucoma, especially in "steroid responders." Regular eye exams are crucial for monitoring intraocular pressure during steroid treatment.

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Genetics

Context:

  • Steroid therapy, while beneficial, is associated with significant ocular side effects.
  • Ocular hypertension and secondary open-angle glaucoma are known risks of corticosteroid use.
  • Approximately one-third of individuals are considered 'steroid responders,' exhibiting elevated intraocular pressure.

Purpose:

  • To review the mechanisms and implications of steroid-induced ocular hypertension and glaucoma.
  • To highlight the role of genetic factors, such as the TIGR/GLCIA gene, in steroid responsiveness.
  • To emphasize the importance of regular ophthalmologic monitoring for patients on steroid treatment.

Summary:

  • Steroid administration (local, regional, inhalation, or systemic) can lead to ocular hypertension and potentially open-angle glaucoma.

Related Experiment Videos

  • Individuals with a family history of open-angle glaucoma are at higher risk.
  • The proposed mechanism involves steroid-induced changes in the trabecular meshwork, possibly via the TIGR/GLCIA gene product, myocilin.

    • Impact:

    • Steroid-induced ocular hypertension is often reversible if treatment duration is less than 12 months.
    • The asymptomatic nature of ocular hypertension necessitates regular eye examinations, including tonometry, visual fields, and optic disc assessment.
    • Early detection and monitoring are vital to prevent irreversible vision loss from steroid-induced glaucoma.