[Juvenile polyposis in Mexican children]
Roberto Cervantes-Bustamante1, Jaime Ramírez-Mayans, Norberto Mata-Rivera
1Servicio de Gastroenterología, Nutrición y Endoscopia, Instituto Nacional de Pediatría (INP), Insurgentes Sur 3700-C, Insurgentes Cuicuilco, CP 04530.
Insights
Juvenile polyposis (JP) in children most commonly presents with lower gastrointestinal bleeding. Rectosigmoidoscopy and colonoscopy are effective diagnostic and therapeutic methods for managing JP.
Area of Science:
- Pediatric Gastroenterology
- Gastrointestinal Pathology
- Diagnostic Endoscopy
Context:
- Juvenile polyposis (JP) affects 3-4% of individuals under 21, accounting for 90% of childhood polyps.
- Common symptoms include hematoquezia, abdominal pain, and polyp prolapse.
- This study analyzed 225 children diagnosed with JP between 1985 and 2000.
Purpose:
- To describe the clinical characteristics, diagnostic methods, and therapeutic outcomes of juvenile polyposis in a pediatric population.
- To evaluate the efficacy of rectosigmoidoscopy and colonoscopy in diagnosing and treating JP.
- To identify the frequency, common locations, and presenting symptoms of juvenile polyps.
Summary:
- The study identified a frequency of one juvenile polyp per 162 patients (0.61%), with the most common age of presentation being 2 to 8 years.
- The rectum was the most frequent site (82%), with polyps located within 6.5 cm of the anal margin on average.
- Rectosigmoidoscopy demonstrated high diagnostic and therapeutic efficacy, negating the need for further barium studies.
Impact:
- Rectosigmoidoscopy and colonoscopy are confirmed as the primary diagnostic and therapeutic modalities for juvenile polyposis in children.
- This research provides valuable data for understanding the epidemiology and management of JP in pediatric patients.
- Highlights the importance of endoscopic procedures in the early detection and treatment of juvenile polyps, improving patient outcomes.
Background:
Juvenile polyposis (JP) is a frequent cause of lower gastrointestinal bleeding. It is present in 3-4% of the population < 21 years of age and represents 90% of all polyps in childhood. The most common complaints are hematoquezia, abdominal pain, and polyp prolapse.
Methods:
A descriptive, observational, transversal study of 225 children with histopatologic diagnosis of JP seen at the Department of Gastroenterology and Nutrition of the Instituto Nacional de Pediatría, between January 1985 and December 2000. Variables studied included age of presentation, gender, frequency, clinical manifestations, type, location, and diagnostic and therapeutic methods.
Results:
Frequency was one polyp per 162 patient seen during the same period (0.61%) and age 2 to 8 years (82%), a total of 235 patients, 120 females and 273 total polyps were found rectum the most common site 82% (224 polyps) followed by sigmoid. Mean distance from anal margin was 6.5 cm. Of all polyps, 82.9% were in the first 10 cm of anal margin. Of all patients, 92.3% had a single polyp and 7.7% had multiple polyps. A baritated study was made in 39 patients (16.6%) with diagnostic efficacy of 74%. No additional baritated studies were needed because of high diagnostic and therapeutic efficacy of the rectosigmoidoscopy.
Conclusions:
Rectosigmoidoscopy and colonoscopy remain as the diagnosis and therapeutic method in children with JP.
Related Concept Videos
01:47Pleiotropy
02:41Lethal Alleles
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
02:23Abnormal Proliferation
02:23Abnormal Proliferation
01:35Polygenic Traits
01:35Polygenic Traits