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MRP1-transfected cells do not show increased resistance against oxidative stress
Aneta Balcerczyk1, Błazej Rychlik, Marcin Kruszewski
1Department of Molecular Biophysics, University of Lódź, 90-237 Lódź, Poland. kbm@biol.uni.lodz.pl
Free Radical Research
|March 26, 2003
Abstract:
Sensitivity of V79 Chinese hamster cells and V79 cells transfected with human MRP1 gene to several agents inducing oxidative stress was compared. Cells overexpressing MRP1 did not show increased resistance to tert-butyl hydroperoxide, diamide, paraquat, menadione, dichromate and carmustine as estimated by cell survival and DNA damage assessed by comet assay. These findings suggest that overexpression of MRP1 does not confer increased resistance to oxidative stress.