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Related Experiment Videos

Malignant ameloblastoma, spindle cell variant.

Richard J Zarbo1, Mark T Marunick, Robert Johns

  • 1Department of Pathology, Henry Ford Hospital, Detroit, MI 48202, USA. rzarbo1@hfhs.org

Archives of Pathology & Laboratory Medicine
|March 26, 2003
PubMed
Summary

This report details a rare, aggressive spindle cell variant of ameloblastoma in a young patient. This epithelial malignancy exhibited malignant behavior, including recurrence and metastasis, over 19 years.

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Area of Science:

  • Oral pathology
  • Oncology
  • Histopathology

Background:

  • Ameloblastoma is a common odontogenic tumor, typically benign, but rare malignant variants exist.
  • Spindle cell morphology in ameloblastoma is uncommon and its malignant potential is not well-defined.
  • Accurate diagnosis is crucial for appropriate management and prognosis.

Observation:

  • A previously undefined spindle cell variant of ameloblastoma was identified.
  • The tumor occurred in the maxilla of a 14-year-old African American female.
  • Histologically, it presented as a well-differentiated, cellular, spindled epithelial proliferation.

Findings:

  • The tumor demonstrated malignant behavior over a 19-year period.
  • The patient experienced multiple local recurrences and distant bone metastases after 15 years.

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  • A final bulky local recurrence with intracranial extension led to death.

    • Implications:

    • This case highlights a rare ameloblastic malignancy that mimics sarcoma.
    • Strong cytokeratin and negative vimentin staining confirm its epithelial origin.
    • Understanding this variant is vital for improved diagnosis and treatment strategies for aggressive odontogenic tumors.