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Effects of age on antibody affinity maturation

D K Dunn-Walters1, M Banerjee, R Mehr

  • 1Department of Histopathology/Immunobiology, GKT Medical School, King's College, 3rd Floor, New Guys House, Guys Hospital, London SE1 9RT, U.K. Deborah.dunn-walters@kcl.ac.uk

Biochemical Society Transactions
|March 26, 2003
PubMed
Summary

Aging impairs the immune system, particularly antibody function, in older adults. Research shows the antibody gene mutation process remains intact, suggesting age-related immune decline stems from altered selection or initial cell differences.

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