Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Centenarians as a model for healthy aging.

C Franceschi1, M Bonafè

  • 1Department of Experimental Pathology, University of Bologna, Bologna, Italy. clafica@alma.unibo.it

Biochemical Society Transactions
|March 26, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chloroprocaine vs. prilocaine for spinal anesthesia in outpatient knee arthroscopy: a prospective economic evaluation using activity-based costing.

European review for medical and pharmacological sciences·2026
Same author

Intricacies of aging and Down syndrome.

Neuroscience and biobehavioral reviews·2024
Same author

Use of chloroprocaine in orthopedic day surgery: a brief report in a cohort of patients undergoing knee arthroscopy.

European review for medical and pharmacological sciences·2023
Same author

Biomarkers of cell damage, neutrophil and macrophage activation associated with in-hospital mortality in geriatric COVID-19 patients.

Immunity & ageing : I & A·2022
Same author

Correction to: A new cognitive clock matching phenotypic and epigenetic ages.

Translational psychiatry·2022
Same author

A new cognitive clock matching phenotypic and epigenetic ages.

Translational psychiatry·2022
Same journal

TDP-43 proteinopathy as a biomarker and therapeutic target in amyotrophic lateral sclerosis.

Biochemical Society transactions·2026
Same journal

Advancing the monitoring of organelle contact sites in vitro and in vivo.

Biochemical Society transactions·2026
Same journal

Mechanisms influencing transient cytoplasmic protein targeting to intracellular lipid droplets.

Biochemical Society transactions·2026
Same journal

Replication associated nuclear DNA mismatch repair across kingdoms.

Biochemical Society transactions·2026
Same journal

Phosphatases of regenerating liver downregulate PTEN to promote tumorigenesis.

Biochemical Society transactions·2026
Same journal

Implications of Rho GTPase signaling in cancer immunotherapy.

Biochemical Society transactions·2026
See all related articles

Centenarian studies reveal aging involves immune system decline (immunosenescence) and chronic inflammation (inflammaging). These factors drive age-related diseases, but strategies like reducing antigen exposure may counteract them.

Area of Science:

  • Gerontology
  • Immunology
  • Genetics

Background:

  • Centenarians provide a model for understanding aging and longevity.
  • Key areas of focus include immunology and genetics.
  • Over a decade of research has been conducted.

Purpose of the Study:

  • To investigate the biological basis of aging and longevity.
  • To analyze changes in the immune system during aging (immunosenescence).
  • To explore the role of chronic inflammation ('inflammaging') in aging and age-related diseases.

Main Methods:

  • Studying centenarians as a model population.
  • Analyzing immunological and genetic factors associated with aging.
  • Observing changes in T cell populations (naïve, memory/effector).

Related Experiment Videos

  • Characterizing the inflammatory status ('inflammaging') in aging.

    • Main Results:

    • Human immunosenescence involves deterioration of clonotypical immunity and preservation of innate immunity.
    • Chronic antigenic stress and thymus involution lead to T cell accumulation and exhaustion.
    • 'Inflammaging,' a chronic inflammatory state, is genetically influenced, detrimental to longevity, and more pronounced in men.
    • Inflammaging is linked to age-related pathologies like neurodegeneration, atherosclerosis, and diabetes.

    Conclusions:

    • Immunosenescence and inflammaging are central to aging and age-related diseases.
    • Strategies to mitigate these processes include reducing antigenic load, eliminating infections, and thymus rejuvenation.
    • Preventative anti-inflammatory treatments may benefit individuals with pro-inflammatory genotypes.