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Mannan-binding lectin and hepatitis C infection.

D C Kilpatrick1, T E S Delahooke, C Koch

  • 1Scottish National Blood Transfusion Service National Science Laboratory, Edinburgh, UK. dave.kilpatrick@snbts.scot.nhs.uk

Clinical and Experimental Immunology
|March 26, 2003
PubMed
Summary

Low mannan-binding lectin (MBL) concentrations do not increase susceptibility to or affect the progression of hepatitis C infection in European patients. MBL levels did not influence treatment response, suggesting MBL replacement therapy is not indicated.

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Area of Science:

  • Immunology
  • Hepatology
  • Virology

Background:

  • Previous studies suggested a link between low mannan-binding lectin (MBL) and hepatitis C (HCV) in Japanese patients.
  • MBL plays a role in innate immunity and pathogen recognition.

Purpose of the Study:

  • To investigate the association between MBL levels and HCV infection in European patients.
  • To determine if low MBL influences HCV susceptibility, disease progression, or treatment response.

Main Methods:

  • Serum MBL concentrations were measured in 180 HCV patients and 566 healthy blood donors.
  • MBL levels were correlated with clinical data, including disease characteristics and antiviral therapy response.

Main Results:

  • Hepatitis C patients had higher MBL concentrations than healthy controls (median 2.5 vs 1.3 microg/ml).

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  • The prevalence of MBL deficiency was similar in both groups.
  • No significant association was found between low MBL and HCV susceptibility, disease progression, or response to interferon and ribavirin therapy.

    • Conclusions:

    • Low circulating MBL does not increase susceptibility to hepatitis C infection in Europeans.
    • MBL concentration does not significantly influence HCV disease course or treatment outcomes.
    • MBL replacement therapy is unlikely to be beneficial for chronic hepatitis C patients unresponsive to standard antiviral treatment.