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Related Experiment Videos

Disseminated gonococcemia.

Khosrow Mehrany1, Joseph M Kist, William J O'Connor

  • 1Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.

International Journal of Dermatology
|March 26, 2003
PubMed
Summary
This summary is machine-generated.

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Disseminated gonococcal infection (DGI) can cause fever, joint pain, and skin lesions. Early diagnosis and treatment with antibiotics like ceftriaxone are crucial for recovery.

Area of Science:

  • Infectious Diseases
  • Dermatology
  • Microbiology

Background:

  • Disseminated gonococcal infection (DGI) is a serious complication of Neisseria gonorrhoeae infection.
  • Early recognition is key to preventing severe outcomes like septic arthritis or meningitis.

Observation:

  • A 26-year-old woman presented with high fever, chills, migratory polyarthralgias, and a characteristic pustular and maculopapular rash.
  • Dermatologic examination revealed hemorrhagic pustules and vesiculopustular lesions on the extremities.
  • Skin biopsy showed neutrophilic infiltrate with leukocytoclasis and Gram-negative diplococci.

Findings:

  • Polymerase chain reaction and blood/throat cultures confirmed Neisseria gonorrhoeae infection.
  • Leukocytosis and positive Gram stain supported the diagnosis of DGI.

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  • Serologic tests for HIV, hepatitis, syphilis, and pregnancy were negative.

    • Implications:

    • Prompt treatment with intravenous ceftriaxone followed by oral cefixime and azithromycin led to rapid clinical improvement.
    • This case highlights the importance of considering DGI in sexually active individuals presenting with fever, arthralgias, and characteristic skin lesions.
    • Effective antibiotic therapy can prevent long-term sequelae of disseminated gonococcal infection.