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[Tumor necrosis factor alpha HLA-DRB(1) gene polymorphism and genetic susceptibility to cirrhosis]

Jusheng Lin1, Yuanqiao Cheng, Deying Tian

  • 1The Institute of Liver Disease, Tongji Hospital, Tongji Medical College, University of Huazhong Science and Technology, Wuhan 430030, China. linjusheng2001@163.net

Zhonghua Nei Ke Za Zhi
|March 26, 2003
PubMed

Insights

Genetic variations in HLA-DRB1 and tumor necrosis factor alpha influence cirrhosis susceptibility. Specifically, HLA-DRB1*120X and TNF2 alleles increase risk, while HLA-DRB1*150X may offer protection against liver cirrhosis.

Area of Science:

  • Immunogenetics
  • Hepatology
  • Molecular Biology

Context:

  • Cirrhosis, a severe liver condition, has complex etiologies.
  • Genetic factors play a role in an individual's susceptibility to developing cirrhosis.
  • Hepatitis B virus (HBV) is a significant cause of cirrhosis globally.

Purpose:

  • To investigate the association between specific gene polymorphisms of HLA-DRB1 and tumor necrosis factor (TNF) alpha and the genetic susceptibility to cirrhosis.
  • To identify potential genetic markers that confer risk or protection against HBV-induced liver cirrhosis.

Summary:

  • This study analyzed the gene polymorphisms of HLA-DRB1 and TNF alpha in 106 HBV-related cirrhosis patients and 108 controls using PCR-SSP and RFLP.
  • Increased frequencies of HLA-DRB1*120X and TNF2 alleles were observed in cirrhosis patients compared to controls.
  • Conversely, the HLA-DRB1*150X allele was less frequent in patients, suggesting a protective role.

Impact:

  • The findings suggest that HLA-DRB1*120X and TNF2 alleles are associated with an increased risk of developing liver cirrhosis.
  • HLA-DRB1*120X may act as a susceptibility gene, while HLA-DRB1*150X may function as a protective gene.
  • These genetic insights contribute to understanding the pathogenesis of cirrhosis and may inform future risk assessment strategies.
Abstract

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