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Design optimization of intraoperative radiotherapy cones
Damian Bernard1, James C H Chu, Martin Rozenfeld
1Departments of Radiation Oncology and Medical Physics, Rush Medical Center, Chicago, IL 60612, USA. jchu@rush.edu
Summary
Optimizing electron intraoperative cones (EIORCs) with internal rings improves radiation therapy. Rings reduce high-dose areas, but their thickness and position are crucial for maintaining treatment volume and dose uniformity.
Area of Science:
- Medical Physics
- Radiation Oncology
- Dosimetry
Background:
- Electron intraoperative cones (EIORCs) are vital for intraoperative radiation therapy (IORT).
- EIORCs can create superficial high-dose regions, posing a challenge for precise treatment delivery.
- Optimizing EIORC design is essential to improve dose conformity and minimize toxicity.
Purpose of the Study:
- To optimize the design of electron intraoperative cones (EIORCs) by investigating the use of internal rings.
- To reduce superficial high-dose regions while preserving the prescribed treatment volume.
- To analyze the impact of ring geometry and material on dose distribution.
Main Methods:
- Monte Carlo simulations were employed to assess dosimetry properties of various EIORC designs.
- Simulations involved varying internal radii, lengths, and material compositions of EIORCs.
- Dose analysis focused on the volume receiving >105% and <90% of the prescription dose.
Main Results:
- High-dose volumes increased with EIORC size and electron beam energy.
- Internal rings effectively reduced the >105% dose volume.
- Ring implementation also increased the <90% dose volume, with changes dependent on ring thickness and position.
Conclusions:
- An optimal ring position of approximately 10 cm from the EIORC base was identified, independent of material, geometry, or energy.
- Optimal ring thickness is contingent upon material composition, beam energy, and the desired balance between dose uniformity and treatment volume preservation.