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[Aminoglycoside antibiotics from a clinical viewpoint]
Schweizerische Medizinische Wochenschrift
|March 27, 1976
Summary
This review compares five aminoglycoside antibiotics, highlighting amikacin
Area of Science:
- Pharmacology
- Microbiology
- Clinical Medicine
Context:
- Aminoglycoside antibiotics are crucial in treating bacterial infections.
- Understanding their properties is vital for effective clinical use.
- Drug interactions, particularly with beta-lactam antibiotics, require careful consideration.
Purpose:
- To review the indications, side effects, dosage, and pharmacokinetics of gentamicin, tobramycin, sisomicin, kanamycin, and amikacin.
- To discuss the use of aminoglycosides in combination with beta-lactam antibiotics.
- To outline the indications for monitoring serum aminoglycoside levels.
Summary:
- Gentamicin, tobramycin, and sisomicin exhibit similar in vitro performance, clinical efficacy, and pharmacology.
- Ototoxicity and nephrotoxicity are noted side effects, with sisomicin, gentamicin, and tobramycin showing decreasing frequency.
- Amikacin's stability against enzymatic inactivation positions it as a primary choice for aminoglycoside-resistant gram-negative bacterial infections.
Impact:
- Provides a comprehensive overview of key aminoglycoside antibiotics for clinicians and researchers.
- Informs therapeutic decisions regarding antibiotic selection and combination therapy.
- Emphasizes the importance of therapeutic drug monitoring for aminoglycosides.