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Activity of and resistance to moxifloxacin in Staphylococcus aureus
Dilek Ince1, Xiamei Zhang, David C Hooper
1Division of Infectious Diseases and Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114-2696, USA.
Antimicrobial Agents and Chemotherapy
|March 26, 2003
Abstract:
Moxifloxacin has enhanced potency against Staphylococcus aureus, lower propensity to select for resistant mutants, and higher bactericidal activity against highly resistant strains than ciprofloxacin. Despite similar activity against purified S. aureus topoisomerase IV and DNA gyrase, it selects for topoisomerase IV mutants, making topoisomerase IV the preferred target in vivo.