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Passive immunity in Helicobacter-challenged neonatal mice conferred by immunized dams lasts until weaning

Irène Corthésy-Theulaz1, Blaise Corthésy, Daniel Bachmann

  • 1Division of Gastroenterology, Nestlé Research Center, CHUV Lausanne, CH-1000 Lausanne 26, Switzerland. irene.corthesy@rdls.nestle.com

Infection and Immunity
|March 26, 2003
PubMed

The objective of this study was to examine the effect of breast-feeding by immunized dams on Helicobacter colonization in newborns. Urease-based immunization regimens failed to protect nursing pups against H. felis, whereas H. felis lysate-cholera toxin resulted in protection. This observation correlated with a high recognition of cell surface-expressed bacterial antigens by milk antibodies. Protection lasted until weaning, indicating that infection is maintained at undetectable levels by passive immunity but then resumes when breast-feeding stops.

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