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A structural and primary sequence comparison of the viral RNA-dependent RNA polymerases
1Department of Biological Sciences, State University of New York, Buffalo, NY 14260, USA. cambruen@nsm.buffalo.edu
Nucleic Acids Research
|March 26, 2003
Abstract:
A systematic bioinformatic approach to identifying the evolutionarily conserved regions of proteins has verified the universality of a newly described conserved motif in RNA-dependent RNA polymerases (motif F). In combination with structural comparisons, this approach has defined two regions that may be involved in unwinding double-stranded RNA (dsRNA) for transcription. One of these is the N-terminal portion of motif F and the second is a large insertion in motif F present in the RNA-dependent RNA polymerases of some dsRNA viruses.