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Updated: Sep 26, 2026

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
08:19

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Tumor necrosis factor signaling

H Wajant1, K Pfizenmaier, P Scheurich

  • 1Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring, Germany. harald.wajant@po.uni-stuttgart.de

Cell Death and Differentiation
|March 26, 2003
PubMed

Insights

Tumor necrosis factor (TNF) is a key cytokine with diverse roles. This review explores TNF

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Tumor necrosis factor (TNF) is a pleiotropic cytokine with significant scientific and clinical interest.
  • Research into TNF's biology began nearly 30 years ago with its described antitumoral effects.

Purpose of the Study:

  • To provide a concise overview of general TNF aspects.
  • To concentrate on the molecular mechanisms of TNF signal transduction.
  • To address the crosstalk between various TNF-engaged signaling pathways.

Main Methods:

  • Literature review of existing research on TNF.
  • Analysis of molecular and cellular mechanisms of TNF signaling.
  • Examination of pathway interactions in TNF biology.

Main Results:

  • TNF exhibits a wide range of biological functions.
  • Significant progress has been made in understanding TNF's in vivo mechanisms.
  • New aspects of TNF biology are continuously being discovered.

Conclusions:

  • A comprehensive understanding of TNF biology is still evolving.
  • Further research is needed to fully elucidate TNF's complex roles.
  • Understanding TNF signal transduction and pathway crosstalk is crucial.

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