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Signet ring-like light chain myeloma with systemic spread.

Joud H Haidar1, Ali Bazarbachi, Michel R Nasr

  • 1Departments of Pathology and Laboratory Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. jh01@aub.edu.lb

European Journal of Haematology
|March 27, 2003
PubMed
Summary

This study reports a rare signet ring-like variant of multiple myeloma (MM). Early recognition of this atypical morphology is crucial for timely diagnosis and treatment of this rare plasma cell disorder.

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Multiple myeloma (MM) typically presents with mature to anaplastic plasma cells.
  • A rare signet ring variant of MM has been reported previously.
  • This case highlights another instance of this unusual morphological presentation.

Observation:

  • A case of signet ring-like lambda light chain MM with extra-skeletal spread to lymph nodes, spleen, and liver is described.
  • The patient exhibited atypical clinical and pathological features.
  • Absence of bone-lytic lesions and monoclonal component on protein electrophoresis complicated the diagnosis.

Findings:

  • The described case represents a rare morphological variant of multiple myeloma.
  • Extra-skeletal involvement was a prominent feature.

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  • Diagnostic delays occurred due to atypical presentation.

    • Implications:

    • Recognizing this rare MM variant is essential for accurate and timely diagnosis.
    • Early identification can improve patient outcomes for this specific subtype of multiple myeloma.
    • This finding contributes to the understanding of MM morphological diversity.