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The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A
María L Souto1, Claudia P Manríquez, Manuel Norte
1Instituto Universitario de Bio-Orgánica, Universidad de La Laguna, Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.
Bioorganic & Medicinal Chemistry Letters
|March 27, 2003
Abstract:
This paper reports testing 15 polyether triterpenes with a squalene carbon skeleton for inhibitory effects on type 2A protein phosphatase. Two compounds, 16-hydroxydehydrothyrsiferol 10 and thyrsenol B 14, exhibited significant inhibitory action at a concentration of 10 microM. Comparison with thyrsiferyl-23-acetate 1 showed that a similar spatial disposition for the hydroxy group around C-15 or C-16 was the structural feature shared by these metabolites.