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[3H]-(R)-NPTS, a radioligand for the type 1 glycine transporter
John A Lowe1, Susan E Drozda, Katherine Fisher
1Central Research Division, Pfizer Inc., Groton, CT 06340, USA. john_a_lowe@groton.pfizer.com
Bioorganic & Medicinal Chemistry Letters
|March 27, 2003
Abstract:
The synthesis of NPTS, 6, a potent inhibitor of the type 1 glycine transporter (GlyT1) is described, as well as preparation of 6 in optically active and tritiated form for use as a radioligand for affinity displacement assay of GlyT1.