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Antibody Profiling by Luciferase Immunoprecipitation Systems (LIPS)
Published on: October 7, 2009
[Antiphospholipid antibodies in HELLP syndrome: clinical and biological study in 68 women]
V Queyrel1, A-S Ducloy-Bouthors, U Michon-Pasturel
1Service de médecine interne, hôpital Claude-Huriez, CHRU de Lille, rue Polonovski, 59037 cedex, Lille, France. v-queyrel@chru-lille.fr <v-queyrel@chru-lille.fr>
Insights
HELLP syndrome, a serious pregnancy complication, may indicate antiphospholipid syndrome. This study investigated anticardiolipin antibodies in HELLP syndrome patients, revealing a potential link between the two conditions.
Area of Science:
- Obstetrics and Gynecology
- Immunology
- Hematology
Context:
- HELLP syndrome (Hemolysis, Elevated Liver enzymes, and Low Platelets) is a severe pregnancy complication.
- Antiphospholipid syndrome (APS) is an autoimmune disorder associated with an increased risk of thrombosis and pregnancy morbidity.
- The co-occurrence of HELLP syndrome and APS is rare, with limited reported cases.
Purpose:
- To investigate the prevalence of anticardiolipin antibodies (aCL) in pregnant women diagnosed with HELLP syndrome.
- To determine if HELLP syndrome can be a presenting manifestation of antiphospholipid syndrome.
- To assess the persistence of aCL in patients following HELLP syndrome.
Summary:
- Anticardiolipin antibodies were detected in 9 out of 68 (13.2%) women with HELLP syndrome.
- The incidence of aCL in HELLP syndrome was 42.8 per 1000 HELLP years.
- Antiphospholipid syndrome was diagnosed in 2 patients, with a prevalence of 0.03% during the study period.
Impact:
- HELLP syndrome may serve as an indicator for underlying antiphospholipid syndrome.
- Early identification of aCL in HELLP syndrome patients could lead to timely APS diagnosis and management.
- This finding highlights the importance of considering autoimmune etiologies in severe obstetric syndromes.
Purpose:
Pregnancy complicated by the HELLP syndrome and antiphospholipid syndrome have rarely been reported. We report a study on anticardiolipin antibodies in HELLP syndrome.
Methods:
Between March 1996 and September 1999, anticardiolipin antibodies were checked in all women with HELLP syndrome hospitalised in a maternity of the North of France. The women with positive anticardiolipin antibodies were seen month later in a internal medicine department.
Results:
In the period 68 women with HELLP syndrome were checked for anticardiolipin antibodies. Apl were present in 9 patients (Incidence 42.8/1000 HELLP Year). They persisted after the accident only in 3 patients. Antiphospholipid syndrome was diagnosed in 2 patients, prevalence between the HELLP syndrome for the 42 month period was 0.03.
Conclusions:
HELLP syndrome may be a manifestation linked to the antiphospholipid syndrome and may revealed it.
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