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Related Experiment Videos

Pulse pressure/stroke index and left ventricular geometry and function: the LIFE Study.

Vittorio Palmieri1, Jonathan N Bella, Mary J Roman

  • 1Weill Medical College of Cornell University, New York, NY 10021, USA. vpalmier@med.cornell.edu

Journal of Hypertension
|March 27, 2003
PubMed
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Increased arterial stiffness, measured by pulse pressure/stroke index ratio (PP/SVi), is linked to specific left ventricular geometry and diastolic dysfunction in hypertensive patients.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Vascular Physiology

Background:

  • Arterial stiffness is a key indicator of cardiovascular risk.
  • Left ventricular (LV) geometry and function are crucial in hypertension management.
  • The relationship between arterial stiffness and LV abnormalities requires further elucidation.

Purpose of the Study:

  • To investigate the association between arterial stiffness, estimated by the pulse pressure/stroke index ratio (PP/SVi), and left ventricular (LV) geometry and function.
  • To identify specific LV abnormalities linked to increased arterial stiffness in hypertensive individuals.

Main Methods:

  • Utilized baseline data from the Losartan Intervention For Endpoint (LIFE) Reduction in Hypertension Study echocardiographic substudy.
  • Included patients with stage II-III hypertension and electrocardiographic LV hypertrophy, excluding those with coronary heart disease or wall motion abnormalities.

Related Experiment Videos

  • Assessed plasma glucose, lipids, creatinine, and urinary albumin/creatinine using standard methods; analyzed PP/SVi in relation to LV parameters.

    • Main Results:

    • Higher PP/SVi correlated with increased age, female proportion, type 2 diabetes, and systolic/mean blood pressures, but lower BMI and height.
    • Increased PP/SVi was associated with concentric LV geometry and higher LV end-systolic stress.
    • Stress-corrected LV chamber function, mitral E/A ratio, and shorter isovolumic relaxation time were greater with higher PP/SVi, independent of confounders.

    Conclusions:

    • Elevated arterial stiffness, indicated by PP/SVi, is associated with concentric left ventricular geometry.
    • Increased arterial stiffness is linked to diastolic abnormalities, suggesting increased diastolic stiffness of the left ventricle.