Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

G x E: a NIAAA workshop on gene-environment interactions.

Lorraine Gunzerath1, David Goldman

  • 1NIAAA Office of Scientific Affairs, National Institutes of Health, 6000 Executive Blvd., Suite 409, Bethesda, MD 20892-7003, USA. lg72x@nih.gov

Alcoholism, Clinical and Experimental Research
|March 27, 2003
PubMed
Summary

This workshop identified key challenges in gene-environment interaction (G x E) research, including study design, costs, and data analysis. Recommendations were proposed to advance G x E studies on alcohol use disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modulation of early non-rapid eye movement slow wave activity by ketamine in treatment-resistant depression.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Recurrent and Non-Recurrent Copy Number Variants in Native Americans and a Cosmopolitan Sample in Relation to Alcohol Use Disorder and Other Psychiatric Diseases.

Molecular neurobiology·2026
Same author

Associations between childhood trauma and amygdala- and insula-centered resting-state functional connectivity in alcohol use disorder.

Journal of psychiatric research·2026
Same author

Genetic regulation of AIF1 shapes immune and liver injury profiles in chronic alcohol use.

JCI insight·2026
Same author

From Gut to Globe: Endogenous Endophthalmitis as a Sentinel Sign of Polymicrobial Intra-Abdominal Infection.

Clinical case reports·2026
Same author

Recurrent & non-recurrent copy number variants in Native Americans and a cosmopolitan sample in relation to Alcohol Use Disorder and other psychiatric diseases.

Research square·2026

Area of Science:

  • Genetics and Behavioral Science
  • Alcohol Research

Background:

  • A workshop sponsored by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) convened experts to address gene-environment interaction (G x E) research.
  • The meeting focused on identifying and overcoming obstacles to G x E studies, particularly in the context of alcohol use disorders.

Framework:

  • The workshop explored G x E research through sessions on animal models, human genetics, phenotypes, study designs, analytical methods, and environmental risk assessment.
  • Discussions highlighted the need for multidisciplinary and multi-institution collaborations to advance the field.

Implementation:

  • Identified challenges included study design and sampling, logistical and methodological costs, data analysis complexities, potential stigmatization, and inadequate organizational structures for large-scale projects.

Related Experiment Videos

  • Recommendations were formulated to address these identified roadblocks and facilitate future G x E research.

    • Implications:

    • The proposed solutions aim to optimize investigative opportunities and foster collaborations within the G x E research community.
    • Facilitating robust G x E studies is crucial for a deeper understanding of the complex interplay between genetic predispositions and environmental factors in alcohol use disorders.