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Over-production of porphyrins and heme in heterotrophic bacteria
Zeitschrift Fur Naturforschung. Section C, Biosciences
|May 1, 1975
Abstract:
In Escherichia coli, Pseudomonas aeruginosa, and Achromobacter metalcaligenes gamma-aminolevulinic acid synthase and gamma-aminolevulinic acid dehydratase appear to be the rate limiting enzymes of porphyrin and heme biosynthesis. Bypassing of these enzymes by addition of gamma-aminolevulinic acid or porphobilinogen results in overproduction of tetrapyrroles.