Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Macrocycles from perhalogenated heterocycles.

Graham Sandford¹

¹Department of Chemistry, University of Durham, South Road, UK. graham.sandford@durham.ac.uk

Chemistry (Weinheim an Der Bergstrasse, Germany)

|March 27, 2003

Summary

Perhalogenated heteroaromatic compounds are versatile building blocks for creating complex macrocyclic and cage-like structures. Their unique properties, including anion recognition, drive further research in this chemical field.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Synthesis of 2,2-difluoro-1,3-diketone and 2,2-difluoro-1,3-ketoester derivatives using fluorine gas.

Beilstein journal of organic chemistry·2024

Same author

Kinetics of Electrophilic Fluorination of Steroids and Epimerisation of Fluorosteroids.

Chemistry (Weinheim an der Bergstrasse, Germany)·2020

Same author

Fluorocyanoesters as Additives for Lithium-Ion Battery Electrolytes.

ACS applied materials & interfaces·2020

Same author

Enolization rates control mono- <i>versus</i> di-fluorination of 1,3-dicarbonyl derivatives.

Chemical science·2020

Same author

<sup>19</sup> F NMR Spectroscopy Tagging and Paramagnetic Relaxation Enhancement-Based Conformation Analysis of Intrinsically Disordered Protein Complexes.

Chembiochem : a European journal of chemical biology·2019

Same author

Lewis acid promoted fluorine-alkoxy group exchange reactions for the synthesis of 5-alkoxy-4,4-difluoroisoxazoline systems.

Organic & biomolecular chemistry·2019

Area of Science:

* Organic Chemistry
* Supramolecular Chemistry

Background:

* Perhalogenated heteroaromatic systems are valuable synthetic precursors.
* Examples include trichloro-s-triazine and pentafluoropyridine.
* These compounds offer unique structural and complexation properties.

Purpose of the Study:

* To explore the synthetic utility of perhalogenated heteroaromatic systems.
* To investigate the formation of macrocyclic and cage-like architectures.
* To highlight the potential of these systems in molecular recognition.

Main Methods:

* Reaction of perhalogenated heteroaromatics with difunctional nucleophiles.
* Synthesis of novel macrocyclic and cage-like compounds.
* Characterization of structural and complexation properties.

Main Results:

* Demonstrated the versatility of perhalogenated heteroaromatics as building blocks.
* Successfully synthesized diverse macrocyclic and cage-like molecular architectures.
* Observed unique complexation characteristics, including anion recognition.

Conclusions:

* Perhalogenated heteroaromatic systems are key components for constructing complex molecular architectures.
* The unusual properties of these systems, particularly anion recognition, warrant further investigation.
* This area holds significant potential for advancements in supramolecular chemistry and materials science.

Related Experiment Videos