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Molecular cytogenetic analysis of a pleuropulmonary blastoma
Bo Hong1, Zhong Chen, Cheryl M Coffin
1Cytogenetics Laboratory, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA.
Cancer Genetics and Cytogenetics
|March 28, 2003
Abstract:
We report a case of pleuropulmonary blastoma with complex cytogenetic abnormalities, including trisomy 2, trisomy 8, dup(7), der(10) t(8; 10)(q13; q22), add(17), and double minutes (dmin). Fluorescence in situ hybridization FISH analysis demonstrated TP53 deletion and amplification of MYCN; the latter has not been reported in PPB.