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Related Experiment Videos

Comparison of analytic approaches for the economic evaluation of new technologies alongside multicenter clinical

Deborah A Taira1, Todd B Seto, Richard Siegrist

  • 1Harvard Clinical Research Institute, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston 02215, USA.

American Heart Journal
|March 28, 2003
PubMed
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Estimating costs in clinical trials significantly impacts results. Using department-level cost-to-charge ratios offers a balanced approach for accurate economic evaluations in cardiovascular research.

Area of Science:

  • Health Economics
  • Clinical Trial Methodology
  • Cardiovascular Interventions

Background:

  • Economic evaluations in clinical trials often lack methodology details for cost estimations.
  • This study addresses the variability in cost estimation methods within multicenter trials.

Purpose of the Study:

  • To compare four distinct methods for estimating patient costs in multicenter clinical trials.
  • To determine the impact of cost estimation methodology on economic evaluation results.

Main Methods:

  • Utilized patient-level data (n=1849) from three percutaneous coronary revascularization trials.
  • Compared four cost estimation methods: hospital charges, hospital cost-to-charge ratios (CCR), department CCR, and itemized costs with department CCR.

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Main Results:

  • Methodology significantly affected cost magnitude but not main economic comparison outcomes.
  • Hospital charges were approximately double the hospital cost estimates.
  • Department-level CCR (method 3) provided cost difference estimates closest to the reference standard.

Conclusions:

  • Cost estimates in cardiovascular clinical trials vary substantially based on accounting methods.
  • Detailed reporting of cost derivation is crucial for clinical decision-making and policy.
  • Department-level CCR offers a practical balance of accuracy and implementation ease for group-level cost comparisons.