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Related Experiment Videos

Insulin decreases human adiponectin plasma levels.

M Möhlig1, U Wegewitz, M Osterhoff

  • 1Department of Endocrinology, Diabetes and Nutrition, Benjamin Franklin Medical Center, Free University Berlin, Germany.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|March 28, 2003
PubMed
Summary

Hyperinsulinemia significantly lowers adiponectin plasma levels in humans. This finding suggests that reduced adiponectin may link high insulin levels to vascular disease in metabolic syndrome.

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Area of Science:

  • Endocrinology
  • Metabolic Syndrome Research
  • Cardiovascular Disease Etiology

Background:

  • Insulin resistance and hyperinsulinemia are established risk factors for atherosclerosis.
  • Adiponectin links obesity, insulin levels, and atherosclerosis, potentially mediating vascular effects of hyperinsulinemia.
  • In vitro studies show insulin reduces adiponectin expression, but in vivo human data are lacking.

Purpose of the Study:

  • To investigate whether insulin regulates adiponectin levels in vivo in humans.
  • To determine the effect of hyperinsulinemia on circulating adiponectin concentrations under euglycemic conditions.

Main Methods:

  • A hyperinsulinemic euglycemic clamp was performed on five healthy male volunteers.
  • Adiponectin plasma levels were measured using radioimmunoassay before and during steady-state hyperinsulinemia.

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  • Blood glucose levels were maintained to isolate the effect of insulin.

    • Main Results:

    • Hyperinsulinemia was successfully induced (85.0 to 482.8 pmol/l; p < 0.01) while maintaining euglycemia (4.6 to 4.37 mmol/l).
    • Adiponectin plasma levels significantly decreased from baseline (30.4 ± 5 µg/ml) to hyperinsulinemic state (26.7 ± 3.5 µg/ml; p < 0.05).

    Conclusions:

    • Hyperinsulinemia significantly reduces circulating adiponectin levels in humans.
    • Hypoadiponectinemia may contribute to the link between hyperinsulinemia and vascular disease in metabolic syndrome.