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Published on: December 19, 2020
Immunogenic protein contaminants in pneumococcal vaccines
Jigui Yu1, David E Briles, Janet A Englund
1Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Abstract:
Currently available pneumococcal vaccines were examined for contamination by pneumococcal surface protein A (PspA) and pneumococcal surface adhesin A (PsaA). PspA could be detected in some (but not all) lots of 23-valent polysaccharide vaccine. Many lots of pneumococcal vaccines, including the heptavalent conjugate vaccine, were found to elicit small (but variable) antibody responses to PspA, PsaA, or both. The degree of contamination was highly variable, and this should be considered in pneumococcal vaccine evaluations or when capsular polysaccharide is used for pneumococcal antibody assays.
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