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Updated: Aug 10, 2026
08:39
Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)
Published on: January 19, 2010
[Collagenous colitis: macroscopically invisible, but with various treatment options]
P Honkoop1, R J Th Ouwendijk, R W M Giard
1Ikazia Ziekenhuis, afd. Interne Geneeskunde, Montessoriweg 1, 3083 AN Rotterdam.
Nederlands Tijdschrift Voor Geneeskunde
|March 29, 2003
Summary
This study reports on collagenous colitis, a chronic watery diarrhea condition. Effective treatments include dietary fiber, sulphasalazine, prednisone, or budesonide, leading to symptom resolution.
Area of Science:
- Gastroenterology
- Histopathology
Background:
- Collagenous colitis is a chronic disorder characterized by watery diarrhea.
- Its etiology and pathogenesis remain largely unknown.
- Macroscopically normal mucosa is observed, with characteristic histological findings.
Observation:
- Two female patients (54 and 67 years) presented with prolonged watery diarrhea.
- Physical, blood, fecal, and endoscopic examinations were unremarkable.
- Intestinal biopsies revealed a thickened subepithelial collagenous layer and increased intraepithelial lymphocytes.
Findings:
- Histological examination confirmed collagenous colitis in both patients.
- Treatment with a high-fiber diet, sulphasalazine, and either prednisone or budesonide resolved symptoms.
- Budesonide has recently shown promising clinical and histological effects.
Implications:
- Collagenous colitis requires specific diagnostic approaches beyond standard examinations.
- A multi-faceted treatment strategy, including newer agents like budesonide, can effectively manage symptoms.
- Further research into the pathogenesis of collagenous colitis is warranted.
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