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Updated: Sep 26, 2026

Evaluation of Amino Acid Consumption in Cultured Bone Cells and Isolated Bone Shafts
Published on: April 13, 2022
[Polyamines and their role in tumor growth]
Joanna Godlewska1, Wanda Peczyńska-Czoch
1Instytut Chemii Organicznej, Biochemii i Biotechnologii Politechniki Wrocławskiej.
Abstract:
The polyamines-putrescine, spermidine and spermine--are normal constituents of prokariotic and eukariotic cells. These small polycationic, aliphatic compounds are essential for normal cell proliferation. Cells cease to proliferate, when they are depleted of their polyamines, but resume a normal growth rate after supplementation with these compounds. Because of the sustained increase in polyamine biosynthesis in preneoplastic and neoplastic tissues, a great deal of interest has been given to the polyamine biosynthesis, network, and uptake systems as a target in antineoplastic strategies.
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