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[The kidneys, ageing and transplantation]
O Viklický1, R Böhmová, U W Heemann
1Klinika nefrologie, Oddĕlení klinické imunologie Transplantacního centra IKEM, Praha. ondrej.viklicky@medicon.cz
Casopis Lekaru Ceskych
|March 29, 2003
Summary
Kidney transplants from elderly donors have lower survival rates and increase chronic rejection risk. This review examines kidney aging and outcomes of elderly donor transplants.
Area of Science:
- Nephrology
- Gerontology
- Transplantation immunology
Context:
- Increasing demand for kidney transplantation exceeds cadaver donor availability.
- Elderly individuals are increasingly considered as potential kidney donors.
- Clinical data indicate reduced graft survival rates from older donors.
Purpose:
- To review the pathophysiological aspects of kidney aging.
- To analyze the outcomes of kidney transplants from elderly donors.
Summary:
- Kidney grafts from aged donors exhibit diminished survival rates compared to younger donors.
- Donor age is a significant risk factor for chronic allograft nephropathy (chronic rejection).
- This review explores kidney aging mechanisms and the fate of elderly donor kidney transplants.
Impact:
- Highlights the challenges and risks associated with using elderly donor kidneys in transplantation.
- Informs clinical decision-making regarding donor selection for kidney recipients.
- Provides insights into mitigating risks of chronic rejection in elderly donor kidney transplants.