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Published on: October 29, 2013
Controlled release from crosslinked degradable networks.
Kelly A Davis1, Kristi S Anseth
1Howard Hughes Medical Institute and Department of Chemical Engineering, University of Colorado-Boulder, Boulder, Colorado 80309, USA.
Critical Reviews in Therapeutic Drug Carrier Systems
|March 29, 2003
Summary
This review covers controlled release from crosslinked degradable networks, including synthetic and natural materials. It explores novel network chemistries for advanced drug delivery applications.
Area of Science:
- Polymer chemistry
- Materials science
- Biomedical engineering
Background:
- Controlled release systems are crucial for drug delivery.
- Crosslinked degradable networks offer tunable properties for release profiles.
- Existing networks utilize various synthetic and natural components.
Purpose of the Study:
- To review controlled release from crosslinked degradable networks.
- To discuss network formulations from synthetic, natural, and combined sources.
- To explore the chemistry of novel degradable networks for controlled release.
Main Methods:
- Literature review of controlled release from crosslinked degradable networks.
- Analysis of network formulations including poly(orthoesters), poly(anhydrides), poly(ethylene glycol) (PEG) derivatives, and dextran functional macromonomers.
- Discussion of the chemistry behind novel degradable networks.
Main Results:
- Crosslinked degradable networks can be formulated from diverse materials.
- Various synthetic polymers like poly(orthoesters) and poly(anhydrides) are suitable.
- Natural polymers and their derivatives, such as dextran, also play a role.
- Combinations of synthetic and natural components offer versatile properties.
Conclusions:
- Crosslinked degradable networks are a promising platform for controlled release.
- The chemistry of these networks dictates their degradation and release kinetics.
- Novel network designs hold potential for advanced drug delivery systems.
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