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Related Experiment Videos

Pulmonary drug delivery systems: recent developments and prospects.

H M Courrier1, N Butz, Th F Vandamme

  • 1Laboratoire de Chimie Thérapeutique et Nutritionnelle, Biodisponibilité Tissulaire et Cellulaire, Faculté de Pharmacie, Université Louis Pasteur, Illkirch, France.

Critical Reviews in Therapeutic Drug Carrier Systems
|March 29, 2003
PubMed
Summary

Pulmonary drug delivery utilizes various carriers like liposomes and microparticles for targeted lung treatments. Innovations include CFC-free inhalers and perfluorooctyl bromide systems for enhanced drug and oxygen delivery.

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Area of Science:

  • Pharmaceutical Sciences
  • Biomedical Engineering
  • Respiratory Medicine

Background:

  • Targeted drug delivery to the lungs is crucial for both local and systemic treatments.
  • Pulmonary drug delivery systems have seen significant development, with inhalation therapy (pMDI, DPI) being a primary method.
  • Intratracheal administration is a common in vivo approach for lung drug delivery.

Purpose of the Study:

  • To review current and emerging drug carriers for pulmonary administration.
  • To discuss advancements in inhalation devices and propellants.
  • To highlight novel systems for combined oxygen and drug delivery in respiratory distress.

Main Methods:

  • Review of existing literature on lung drug delivery carriers and devices.
  • Discussion of various pharmaceutical carriers such as liposomes, nanoparticles, microparticles, and microemulsions.

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  • Analysis of microreservoir-type systems for controlled drug release and high loading capacity.

    • Main Results:

    • Various carriers (liposomes, nanoparticles, microparticles, etc.) are effective for lung drug targeting.
    • Microreservoir systems offer advantages in drug loading and controlled release kinetics.
    • New systems, including CFC-free inhalers and perfluorooctyl bromide-based formulations, are advancing pulmonary drug delivery.

    Conclusions:

    • Diverse drug carriers are successfully employed for pulmonary drug delivery.
    • Advanced carrier systems enable efficient drug targeting and controlled release in the lungs.
    • Emerging technologies promise improved therapeutic outcomes for respiratory conditions.